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邓宏魁

发布日期:2016-05-05 访问次数: 字号:[ ]


  

      

邓宏魁

       简  历

  北京大学基础医学院细胞生物系主任

  北京大学干细胞研究中心主任

  北京大学-清华大学生命科学联合中心研究员

  E-mail: hongkui_deng@pku.edu.cn

  主要研究方向

  体细胞重编程,细胞命运调控的分子机制

  再生医学,组织器官再生

  肿瘤的免疫治疗

  

  教育经历

  1980~1984年          中国武汉大学,学士

  1984~1987年          中国上海第二医科大学,硕士

  1990~1995年          美国加州大学洛杉矶分校,博士

  1995~1997年         美国纽约大学医学中心, 博士后研究

  

  代表性论文

  1.Zhao Y, Zhao T, Guan J, Zhang X, Fu Y, Ye J, Zhu J, Meng G, Ge J, Yang S, Cheng L, Du Y, Zhao C, Wang T, Su L, Yang W, Deng H. A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming, Cell. 2015; 163:1678-91.

  2.Li X, Zuo X, Jing J, Ma Y, Wang J, Liu D, Zhu J, Du X, Xiong L, Du Y, Xu J, Xiao X, Wang J, Chai Z, Zhao Y, Deng H. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015;17:195-203.

  3.Xu J, Du Y, Deng H. Direct lineage reprogramming: strategies, mechanisms, and applications. Cell Stem Cell. 2015;16(2):119-34. Review

  4.Fang R, Liu K, Zhao Y, Li H, Zhu D, Du Y, Xiang C, Li X, Liu H, Miao Z, Zhang X, Shi Y, Yang W, Xu J, Deng H. Generation of naive induced pluripotent stem cells from rhesus monkey fibroblasts. Cell Stem Cell. 2014; 15(4):488-96.

  5.Du Y, Wang J, Jia J, Song N3 Xiang C, Xu J, Hou Z, Su X, Liu B, Jiang T, Zhao D, Sun Y, Shu J, Guo Q, Yin M, Sun D, Lu S, Shi Y, Deng H. Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. Cell Stem Cell. 2014 ;14:394-403.

  6.Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013, 341(6146):651-4.

  7.Shu J, Wu C, Wu Y, Li Z, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, Yang W, Shi Y, Chi X, Zhang H, Gao G, Shu Y, Yuan K, He W, Tang C, Zhao Y, Deng H. Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell. 2013, 153(5):963-75.

  8.Sun X, Xu J, Lu H, Liu W, Miao Z, Sui X, Liu H, Su L, Du W, He Q, Chen F, Shi Y, Deng H. Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo. Cell Stem Cell. 2013,13(2):230-6.

  9.Li W, Wei W, Zhu S, Zhu J, Shi Y, Lin T, Hao E, Hayek A, Deng H and Ding S. Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors. Cell Stem Cell. 2009, 4(1):16-9.

  10.Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H, Jiang W, Cai J, Liu M, Cui K, Qu X, Xiang T, Lu D, Chi X, Gao G, Ji W, Ding M, Deng H. Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts. Cell Stem Cell. 2008, 3(6):587-90.

  11.Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell. 2008, 3(5):475-9.

  12.Deng, H., Unutmaz, D., Kewalramani, V., and Littman, D.R. Expression cloning of novel coreceptors utilized by the simion and human immunodeficency viruses. Nature. 1997. 388:296-300 .

  13.Deng, H., Liu, R., Ellmeier, W., Choe, S., Untmaz, D., Burkhart, M., Marazio, P.D., Marmon, S., Sutton, R.E., Hill, C.M., Davis, C.B., Peiper, S.C., Schall, T.J., Littman, D.R. Identification of a major co-receptor for primary isolates HIV-1. Nature. 1996. 381:661-666.

  

  





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